Investigation of Homocysteine, Vitamin B6 and Vitamin D among Patients with Colorectal Cancer

Abstract

Background and objectives: Colorectal cancer (CRC) is a disease that begins exclusively in the
colon or rectum and is caused by the abnormal growth of glandular epithelial cells within the colon.
Homocysteine, vitamin B6, and vitamin D are recognized to play a significant role in colorectal tumor
pathogenesis. The aim of this study to investigate serum levels of Hcy, vitamin D and vitamin B6 in
colorectal cancer.
Methods: The current study investigated the vital roles of homocysteine, vitamin B6 and vitamin D in
cancer development by comparing serum levels of colorectal cancer patients with those of the healthy
control group at Nanakaly hospital. The levels of serum homocysteine (Hcy), vitamin B6 and vitamin D
in 50 colorectal cancer patients and 50 from the healthy control group have been examined.
Results: The result shows significantly high values of serum homocysteine (p<0.0001) and
significant decreases in values of vitamin B6 and vitamin D (p<0.0001and 0.0010) respectively, in
patients with CRC when compared with the healthy group.
Conclusions: Our findings demonstrate that increased levels of homocysteine and decreased levels
of vitamin B6 and vitamin D could be associated with the pathogenesis and progression of colorectal
cancer.